AI & Computing

Why I Quantize Open-Weight Models for Macs — And Why Your Law Firm Should Care

Frontier cloud LLMs log your prompts. For privileged content — NDAs, medical records, source protection — that’s a deal-breaker. Open weights on Apple Silicon are the only honest answer, and there’s real, sustained demand from firms that nobody is talking about.

Why I Quantize Open-Weight Models for Macs — And Why Your Law Firm Should Care Read Post »

504,571 Brain Cells, 4 Labs, One Hypothesis: A Citizen Pass at Parkinson’s

I’m not a neuroscientist. But I pooled 504,571 single-cell measurements from four research groups and ran the meta-analysis. AGTR1+ dopamine neurons are depleted in every Parkinson’s cohort, combined p < 10^-100. The receptor is targetable by FDA-approved blood-pressure drugs.

504,571 Brain Cells, 4 Labs, One Hypothesis: A Citizen Pass at Parkinson’s Read Post »

Shopping Cart
Scroll to Top